objective(s):the present study investigated the effect of long-term mild cerebral hypoperfusion induced by permanent unilateral (right) common carotid artery occlusion (uco) on the dorsal hippocampal neurons in rats. materials and methods:sixty four male sprague-dawley rats aged 4 months were divided into two groups of sham and uco. these two groups were further divided into 4 sets of histopath...

seizure may occur after mild traumatic brain injury (tbi), and the severity of tbi can be considered the most crucial factor for an increased risk of recurring seizures as well as for the development of posttraumatic epilepsy. however, the effect of seizures in epileptogenesis after mild tbi cannot yet be accurately confirmed. this study was designed to determine whether mild tbi increases seiz...

due to the worldwide increase in the number of older people in both developed and developing countries, there is a public health concern for dealing with age related diseases such as neurodegenerative diseases. there is little known about the difference in neuronal cell responses between genders. our understanding of the neuronal cell response regarding genders, will be useful for developing mo...

introduction: dna damage, as an important initiator of neuronal cell death, has been implicated in numerous neurodegenerative conditions. previously we have delineated several pathways that control embryonic cortical neuronal cell death evoked by the dna-damaging agent, camptothecin. the camptothecin, topoisomerase ι inhibitor, has been shown to induce cortical neuronal cell death in a reproduc...

many studies indicate that oxidative stress is involved in the pathophysiology of neurodegenerative diseases. oxidative stress can induce neuronal damages, modulate intracellular signaling and ultimately leads to neuronal death by apoptosis or necrosis. to review antioxidants preventive effects on oxidative stress and neurodegenerative diseases we accumulated data from international medical jou...

Many studies indicate that oxidative stress is involved in the pathophysiology of neurodegenerative diseases. Oxidative stress can induce neuronal damages, modulate intracellular signaling and ultimately leads to neuronal death by apoptosis or necrosis. To review antioxidants preventive effects on oxidative stress and neurodegenerative diseases we accumulated data from internatio...